JOCS
Journal of Comprehensive Surgery

The aim of the Comprehensive Surgery is to publish original research articles of the highest scientific and clinical value at the international level in all surgical fields.

eISSN: 2980-0862
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Original Article
Cervical human papillomavirus infection and cytologic abnormalities in patients with vulvar squamous cell carcinoma
Abstract
Aims: To assess the prevalence of cervical human papillomavirus (HPV) infection and related cytologic or histopathologic abnormalities in patients with vulvar squamous cell carcinoma (VSCC), and to explore their association with HPV-related and HPV-independent tumor subtypes.
Methods: This retrospective study included 41 surgically treated VSCC patients at Ankara Bilkent City Hospital (2019-2024). Clinical, cytologic, and pathologic data, including vulvar and cervical HPV status, were analyzed. Cervical HPV testing was performed by Polymerase Chain Reaction (PCR), and cytology was classified according to the Bethesda system.
Results: HPV-associated VSCC was identified in 17.1% of patients, and cervical HPV positivity in 7.1%. Among 34 cytology results, 32.4% showed abnormalities (ASCUS, ASC-H, or HSIL). Cervical biopsy revealed LSIL or HSIL in 6 patients and invasive carcinoma in 1. Preinvasive or invasive cervical lesions were more frequent in HPV-associated VSCC (57.1%) than in HPV-independent cases (28.6%), though not statistically significant (p=0.204).
Conclusion: Cervical HPV infection and cytologic abnormalities were uncommon, likely reflecting the predominance of HPV-independent tumors in this older cohort. Nevertheless, abnormal cytology in a subset of patients supports comprehensive cervical assessment and risk-adapted surveillance, particularly in HPV-associated VSCC.

Keywords : Vulvar squamous cell carcinoma, human papillomavirus, cervical cytology

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1. Virarkar M, Vulasala SS, Daoud T, Javadi S, Lall C, Bhosale P. Vulvar cancer: 2021 revised FIGO staging system and the role of imaging. Cancers (Basel). 2022;14(9):2264. doi:10.3390/cancers14092264
2. de Bie RP, van de Nieuwenhof HP, Bekkers RL, et al. Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities. Br J Cancer. 2009;101(1):27-31. doi:10.1038/sj.bjc.6605124
3. Li Z, Liu P, Wang Z, et al. Prevalence of human papillomavirus DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol. 2023;24(4):403-414. doi:10.1016/S1470-2045(23)00066-9
4. Bucchi L, Pizzato M, Rosso S, Ferretti S. New insights into the epidemiology of vulvar cancer: systematic literature review for an update of incidence and risk factors. Cancers (Basel). 2022;14(2):389. doi:10.3390/cancers14020389
5. Hampl M, Wentzensen N, Vinokurova S, et al. Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile. J Cancer Res Clin Oncol. 2007;133(4):235-245. doi:10.1007/s00432-006-0162-0
6. Vinokurova S, Wentzensen N, Kraus I, et al. Type-dependent integration frequency of human papillomavirus genomes in cervical lesions. Cancer Res. 2008;68(1):307-313. doi:10.1158/0008-5472.CAN-07-2754
7. Buchanan TR, Zamorano AS, Massad LS, et al. Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: a 6 year follow-up study. Gynecol Oncol. 2019;155(1):88-92. doi:10.1016/j.ygyno.2019.07.017
8. Oonk MHM, Planchamp F, Baldwin P, et al. European Society of Gynaecological Oncology Guidelines for the management of patients with vulvar cancer. Int J Gynecol Cancer. 2017;27(4):832-837. doi:10.1097IGC.0000000000000975
9. Carreras-Dieguez N, Saco A, Del Pino M, et al. Human papillomavirus and p53 status define three types of vulvar squamous cell carcinomas with distinct clinical, pathological, and prognostic features. Histopathology. 2023;83(1):17-30. doi:10.1111/his.14925
Article available in :
Volume 3, Issue 4, 2025
Page : 68-71
https://doi.org/10.51271/JOCS-0063
Article Information
Received : 25 Eki 2025
Accepted : 17 Kas 2025
Published : 29 Kas 2025
Corresponding Author :

Arife Ebru Taşçı: Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Ankara, Turkiye

[email protected]
Citation : Taşcı AE, Aytekin O, Altaş H, et al. Cervical human papillomavirus infection and cytologic abnormalities in patients with vulvar squamous cell carcinoma. J Compr Surg. 2025;3(4):68-71.

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