JOCS
Journal of Comprehensive Surgery

The aim of the Comprehensive Surgery is to publish original research articles of the highest scientific and clinical value at the international level in all surgical fields.

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Case Report
Black seed oil induced acute liver failure: a case report and literature review
Abstract
Acute liver failure (ALF) is a clinical condition that develops suddenly in individuals with no history of liver disease due to various factors and has a high morbidity and mortality rate. Drugs, chemicals, and herbal products are the leading causes of ALF. Black seed is widely used among the population due to its diuretic, antihypertensive, antidiabetic, anticancer, antimicrobial, anti-inflammatory, gastroprotective, hepatoprotective, kidney-protective, and antioxidant properties. In this report, an 82-year-old female patient with a history of diabetes, hypertension, and chronic kidney disease who received hemodialysis treatment twice a week was examined for ALF due to black seed oil use. The patient, who applied to the emergency room with confusion, had increased liver function tests in laboratory findings. In addition, no pathology was detected in the patient's CT angiography and ultrasonography other than grade 1 steatosis and increased linear echogenicity in the liver. The patient, who was diagnosed with ALF, started treatment in the intensive care unit. The patient, who had a poor prognosis in the intensive care unit, died on the 9th day of her hospitalization. Considering the studies in the literature and the patient we examined, although it is thought to be harmless among the public, herbal products should not be used with medications and in patients receiving renal replacement therapy without the advice of a physician or pharmacist due to their possible toxic effects.

Keywords : Acute liver failure, herbal products, black seed

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1. Axley P, Ahmed Z, Arora S, et al. NASH Is the most rapidly growing etiology for acute-on-chronic liver failure-related hospitalization and disease burden in the United States: a population-based study. Liver Transpl. 2019;25(5):695-705. doi:10.1002/lt.25443
2. Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Liver injury from herbal and dietary supplements. Hepatology. 2017; 65(1):363-373. doi:10.1002/hep.28813
3. Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pacific J Tropical Biomed. 2013; 3(5):337-352. doi:10.1016/s2221-1691(13)60075-1
4. Hannan MA, Rahman MA, Sohag AAM, et al. Black cumin (Nigella sativa L.): a comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients. 2021;13(6):1784. doi:10. 3390/nu13061784
5. Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med. 2016;14(10):732-745. doi: 10.1016/s1875-5364(16)30088-7
6. Amin B, Hosseinzadeh H. Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects. Planta Med. 2016;82(1-2):8-16. doi:10. 1055/s-0035-1557838
7. Stournaras E, Tziomalos K. Herbal medicine-related hepatotoxicity. World J Hepatol. 2015;7(19):2189-2193. doi:10.4254/wjh.v7.i19.2189
8. Claure-Del Granado R, Espinosa-Cuevas M. Herbal nephropathy. Contribut Nephrol. 2021;199:143-154. doi:10.1159/000517693
9. Tovar RT, Petzel RM. Herbal toxicity. Dis Mon. 2009;55(10):592-641. doi:10.1016/j.disamonth.2009.05.001
10. Badary OA, Al-Shabanah OA, Nagi MN, Al-Bekairi AM, Elmazar MMA. Acute and subchronic toxicity of thymoquinone in mice. Drug Develop Res. 1998;44(2-3):56-61. doi:10.1002/(SICI)1098-2299(199806/07)44:2/3
11. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002;9(1):69-74. doi:10.1078/0944-7113-00084
12. Zedlitz S, Kaufmann R, Boehncke WH. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment. Contact Dermatit. 2002;46(3):188. doi:10.1034/j.1600-0536.2002.460318.x
13. Steinmann A, Schätzle M, Agathos M, Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatit. 1997;36(5):268-269. doi:10.1111/j.1600-0536.1997.tb00219.x
14. Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 2013;148(3):780-786. doi:10.1016/j.jep.2013.05.004
15. Akhondian J, Kianifar H, Raoofziaee M, Moayedpour A, Toosi MB, Khajedaluee M. The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Res. 2011;93(1):39-43. doi:10.1016/j.eplepsyres.2010.10.010
16. Sener K, Cakir A, Yesiloglu O, Altug E, Guven R, Korkut S. Rhabdomyolysis and acute kidney injury after consumption of black seed oil. Toxicon. 2024;245:107787. doi:10.1016/j.toxicon.2024.107787<br />
Article available in :
Volume 3, Issue 2, 2025
Page : 37-39
https://doi.org/10.51271/JOCS-0054
Article Information
Received : 15 Oca 2025
Accepted : 11 Şub 2025
Published : 08 May 2025
Corresponding Author :

Eyüp Can Polat: Department of Clinical Pharmacy, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkiye

[email protected]
Citation : Polat EC, Zorbuna S, Koç A. Black seed oil induced acute liver failure: a case report and literature review. J Compr Surg. 2025;3(2):37-39.

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