The aim of the Comprehensive Surgery is to publish original research articles of the highest scientific and clinical value at the international level in all surgical fields. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Original Article
The comparison of corneal endothelium morphology through specular microscopy in morbid obesity with healthy controls
Aims: To evaluate the morphological changes in corneal endothelial cells with morbid obesity, and to analyze the relationship between BMI and corneal endothelial features.
Methods: The central corneal thickness (CCT), the average endothelial cell density (ECD) (cell/mm²), average cell area (CA) (µm²), coefficient of variation of cell area (CV)- (CV: Standard deviation/CA) values were recorded via specular microscopy in morbidly obese patients and controls. The whole parameters were compared.
Results: The morbid obese patients had significantly thicker corneas (p=0.013), and significant loss of hexagonality (p=0.012) compared with controls, while there was no significant difference in ECD (p=0.311), CA (p=0.292), and CA (p=0.161). In linear regression analysis, there was no significant correlation between CCT, abdominal circumference, and the endothelium parameters.
Conclusion: Although BMI has the effect of changing corneal morphology, this change is not correlated with an increase in BMI.

1. Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol.2007;52(2):180-195. Available from:
2. Üstün Y, Köksal E. Obezite ve anestezi. J Experiment Clin Med.2013;30(1s):15-23.
3. Ricci MA, De Vuono S, Scavizzi M, Gentili A, Lupattelli G. Facingmorbid obesity: how to approach it. Angiol. 2016;67(4):391-397.Available from:
4. Gonul S, Yilmaz H, Gedik S, Ozturk BT, Oflaz AB, Sahin M. Evaluationof the choroidal thickness and retinal nerve fiber layer, and visual fieldin morbid obesity: does bariatric surgery affect retinal structure andfunction? Indian J Ophthalmol. 2021;69(2):301306.
5. Şahin Vural G, Çay F. The recovery of ocular surface after bariatricsurgery in morbid obese patients. J Heal Sci Med. 2022;5(4):938-941.
6. Çay F, Şahin Vural G. Evaluation of the alteration in retinal featuresfollowing bariatric surgery in patients with morbid obesity. J Heal SciMed. 2022;5(3):789-793.
7. Gupta PK, Berdahl JP, Chan CC, Rocha KM, Yeu E, Ayres B, et al. Thecorneal endothelium: clinical review of endothelial cell health andfunction. J Cataract Refract Surg. 2021;47(9):1218-1226.
8. Bu J, Yu J, Wu Y, Cai X, Li K, Tang L, et al. Hyperlipidemia affectstight junctions and pump function in the corneal endothelium.Am J Pathol. 2020;190(3):563-576.
9. Gürlü PV, Bülbül ED, Erdal S. Nonkontakt speküler mikroskop ileyapılan otomatik endotel hücre analizlerinin tekrarlanabilirliği. TürkOftalmol Derg. 2006;36(4):300-305.
10. AC U. Speküler mikroskopi ve konfokal mikroskopi-çalışmamekanizmaları ve oftalmolojideki uygulamaları. Türkiye Klin OftalmolDerg. 2011;20(2):89-98.
11. Lundberg B, Jonsson M, Behndig A. Postoperative cornealswelling correlates strongly to corneal endothelial cell lossafter phacoemulsification cataract surgery. Am J Ophthalmol.2005;139(6):1035-1041.
12. Gipson IK. Age-related changes and diseases of the ocular surface andcornea. Invest Ophthalmol Vis Sci. 2013;54(14):48-53.
13. Bourne WM, Nelson LR, Hodge DO. Central corneal endothelialcell changes over a ten-year period. Invest Ophthalmol Vis Sci.1997;38(3):779-782.
14. Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol.2007;52(2):180-195.
15. Konieczka K, Flammer J. Phenomenology and clinical relevance of theflammer syndrome. Klin Monbl Augenheilkd. 2016;233(12):1331-1336.
16. Zhao X, Bo Q, Sun J, Chen J, Li T, Huang X, et al. The associationbetween obesity and glaucoma in older adults: evidence from the Chinahealth and retirement longitudinal study. Epidemiol Health. 2023;45.
Volume 1, Issue 4, 2023
Page : 78-81