The aim of the Comprehensive Surgery is to publish original research articles of the highest scientific and clinical value at the international level in all surgical fields. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Case Report
A rare case of giant adrenal ganglioneuroma
Ganglioneuromas (GN) are rare benign tumors that typically occur in the posterior mediastinum or retroperitoneal region, but can also be found in adrenal glands. Up to 50% of patients are asymptomatic, but symptoms can arise from the mass effect or excessive secretion of catecholamines. Careful evaluation is necessary to differentiate GNs from other adrenal tumors. A 19-year-old female patient with no previous comorbidities was diagnosed with a right adrenal incidentaloma. Physical examination and routine laboratory tests were normal. Imaging revealed a solid lesion in the right adrenal gland, and excisional adrenalectomy was performed. Pathological examination confirmed the diagnosis of a right adrenal GN. The patient had an uneventful recovery and showed no recurrence during the follow-up period. Conclusion: After surgical removal of a benign neurogenic tumor, our patient had no tumor recurrence after five months, indicating a positive prognosis. However, long-term follow-up is still recommended because of reported cases of metastases and recurrence in some patients.

1. Shimada H, Ambros IM, Dehner LP, et al. The internationalneuroblastoma pathology classification (the shimada system). Cancer.1999;86(2):364-372.
2. Carpenter WB, Kernohan JW. Retroperitoneal ganglioneuromas andneurofibromas. a clinicopathological study. Cancer. 1963;16(6):788-797.
3. Geoerger B, Hero B, Harms D, Grebe J, Scheidhauer K, Berthold F.Metabolic activity and clinical features of primary ganglioneuromas.Cancer. 2001;91(10):1905-1913.
4. Lucas K, Gula MJ, Knisely AS, et al. Catecholamine metabolites inganglioneuroma. Med Pediatr Oncol. 1994;22(4): 240-243.
5. Rondeau G, Nolet S, Latour M, et al. Clinical and biochemical featuresof seven adult adrenal ganglioneuromas. J Clin Endocrinol Metab.2010;95(7):3118-3125.
6. Qing Y, Bin X, Jian W, et al. Adrenal ganglioneuromas: a 10-yearexperience in a Chinese population. Surgery 2010;147(6):854-860.
7. Maweja S, Materne R, Detrembleur N, et al. Adrenal ganglioneuroma. aneoplasia to exclude in patients with adrenal incidentaloma. Acta ChirBelg. 2007;107(6):670-674.
8. Linos D, Tsirlis T, Kapralou A, Kiriakopoulos A, Tsakayannis D,Papaioannou D. Adrenal ganglioneuromas: incidentalomas withmisleading clinical and imaging features. Surgery. 2011;149(1):99-105.
9. Ilias I, Sahdev A, Reznek RH, Grossman AB, Pacak K. The optimalimaging of adrenal tumors: a comparison of different methods. EndocrRelat Cancer. 2007;14(3):587-599.
10. Sasaki S, Yasuda T, Kaneto H, et al. Large adrenal ganglioneuroma.Intern Med. 2012;51(17):2365-2370.
11. Yamaguchi K, Hara I, Takeda M, et al. Two cases of ganglioneuroma.Urology. 2006;67(3):622.
12. Grumbach MM, Biller BM, Braunstein GD, et al. Management of theclinically inapparent adrenal mass (“incidentaloma”). Ann Intern Med.2003;138(5):424-429.
13. JoshiVV. Peripheral neuroblastic tumors: pathologic classificationbased on recommendations of international neuroblastoma pathologycommittee (modification of shimada classification). Pediatr Dev Pathol.2000;3(2):184-199.
14. Mylonas KS, Schizas D, Economopoulos KP. Adrenal ganglioneuroma:what you need to know. World J Clin Cases. 2017;5(10):373-377.
15. Brunt LM, Moley JF. Adrenal incidentaloma. World J Surg. 2001;25:905-913.
16. Zografos GN, Kothonidis K, Ageli C, et al. Laparoscopic resection oflarge adrenal ganglioneuroma. JSLS. 2007;11(4):487-492.
17. Zhang Y, Nishimura H, Kato S, et al. MRI of ganglioneuroma: histologiccorrelation study. J Comput Assist Tomogr. 2001;25(4):617-623.
18. Kulkarni AV, Bilbao JM, Cusimano MD, Muller PJ. Malignanttransformation of ganglioneuroma into spinal neuroblastoma inan adult. case report. J Neurosurg. 1998;88(2):324-327. doi: 10.3171/jns.1998.88.2.0324.PMID: 9452244
Volume 1, Issue 4, 2023
Page : 100-103