The aim of the Comprehensive Surgery is to publish original research articles of the highest scientific and clinical value at the international level in all surgical fields. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Original Article
Evaluation of the systemic inflammatory response in patients with a spinal synovial cyst or lumbar disc herniation
Aims: This study aimed to determine whether a systemic inflammatory response occurs in patients with spinal synovial cysts (SSC) and patients with lumbar disc herniation.
Methods: Patients who underwent surgery for SSC or lumbar disc herniation between 2016-2022 were included in the study. To compare the results of these patients, patients who applied to the outpatient clinic due to headaches but did not find any abnormal findings in the radiological examinations were also included. Age, gender, duration of stay in the hospital, comorbidity, and histopathological evaluation results were recorded for all patients. The lumbar T2 weighted MR sagittal and axial images obtained on admission to the hospital were examined. The venous blood samples taken from the patients on first admission to the hospital were analyzed biochemically.
Results: There was no statistical difference between the three groups regarding age, gender, and blood biochemistry parameters. Furthermore, no statistical difference was found between SSC patients and patients with lumbar disc herniation in age, gender, cyst or herniated disc localization levels, comorbidity, and blood biochemistry analysis results. Correlation analysis for the findings of all patients revealed that no parameters were correlated with the study groups. ROC-Curve test and Logistic Regression tests showed that no parameter could be a predictive marker in differentiating SSC from disc herniation.
Conclusion: Study results demonstrated that neither SSC nor disc herniation caused a systemic inflammatory or allergic reaction in the patients. In addition, it was determined that no biochemical parameter could distinguish disc herniation from SSC.

1. Al-Saidi I, Pascoe M, Tabbaa K. Fluoroscopy-Guided TransfacetLumbar Epidural Steroid Injection for Symptomatic Synovial CystTreatment: A Case Report. A A Pract. 2020;14(11):e01312. doi: 10.1213/XAA.0000000000001312.
2. Apostolaki E, Davies AM, Evans N, Cassar-Pullicino VN. MR imagingof lumbar facet joint synovial cysts. Eur Radiol. 2000;10(4):615-23. doi:10.1007/s003300050973.
3. Campbell RJ, Mobbs RJ, Rao PJ, Phan K. Interventions for LumbarSynovial Facet Joint Cysts: A Comparison of Percutaneous, SurgicalDecompression and Fusion Approaches. World Neurosurg. 2017;98:492-502. doi: 10.1016/j.wneu.2016.11.044.
4. Campbell R, Phan K, Mobbs R. Classification of Lumbar Facet JointCysts Using the NeuroSpine Surgery Research Group (NSURG) GradingScore and Correlation with Recurrence and Clinical Outcomes. WorldNeurosurg. 2018;119:e502-e512. doi: 10.1016/j.wneu.2018.07.190.
5. Chebib I, Chang CY, Schwab JH, Kerr DA, Deshpande V, NielsenGP. Histopathology of synovial cysts of the spine. Histopathology.2018;72(6):923-929. doi: 10.1111/his.13465.
6. Ewald C, Kalff R. Resolution of a synovial cyst of the lumbar spinewithout surgical therapy -- a case report. Zentralbl Neurochir.2005;66(3):147-51. doi: 10.1055/s-2005-836475.
7. Finckh A, Gerster J, So AK. Association of spondylarthropathies withlumbar synovial cysts. Clin Rheumatol. 2003;22(1):67-9. doi: 10.1007/s10067-002-0656-3.
8. Fletcher-Sandersjöö A, Edström E, Kuntze Söderqvist Å, Grane P,Elmi-Terander A. Long-term pain relief following percutaneoussteroid treatment of spinal synovial cysts: a population-basedcohort study. J Neurointerv Surg. 2020;12(9):874-878. doi: 10.1136/neurintsurg-2020-015890.
9. Houten JK, Sanderson SP, Cooper PR. Spontaneous regression ofsymptomatic lumbar synovial cysts. Report of three cases. J Neurosurg.2003;99(2 Suppl):235-8. doi: 10.3171/spi.2003.99.2.0235.
10. Kusakabe T, Kasama F, Aizawa T, Sato T, Kokubun S. Facet cyst in thelumbar spine: radiological and histopathological findings and possiblepathogenesis. J Neurosurg Spine. 2006;5(5):398-403. doi: 10.3171/spi.2006.5.5.398.
11. Mattei TA, Goulart CR, McCall TD. Pathophysiology of regression ofsynovial cysts of the lumbar spine: the ‘anti-inflammatory hypothesis’.Med Hypotheses. 2012;79(6):813-8. doi: 10.1016/j.mehy.2012.08.034.
12. Métellus P, Fuentes S, Adetchessi T, Levrier O, Flores-Parra I, TalianuD, Dufour H, Bouvier C, Manera L, Grisoli F. Retrospective study of 77patients harbouring lumbar synovial cysts: functional and neurologicaloutcome. Acta Neurochir (Wien). 2006;148(1):47-54; discussion 54. doi:10.1007/s00701-005-0650-z.
13. Parlier-Cuau C, Wybier M, Nizard R, Champsaur P, Le Hir P, LaredoJD. Symptomatic lumbar facet joint synovial cysts: clinical assessmentof facet joint steroid injection after 1 and 6 months and long-termfollow-up in 30 patients. Radiology. 1999;210(2):509-13. doi: 10.1148/radiology.210.2.r99fe60509.
14. Rosenstock T, Vajkoczy P. New classification of facet joint synovialcysts. Acta Neurochir (Wien). 2020;162(4):929-936. doi: 10.1007/s00701-020-04264-2.
15. Sabo RA, Tracy PT, Weinger JM. A series of 60 juxtafacet cysts: clinicalpresentation, the role of spinal instability, and treatment. J Neurosurg.1996;85(4):560-5. doi: 10.3171/jns.1996.85.4.0560.
16. Tillich M, Trummer M, Lindbichler F, Flaschka G. Symptomaticintraspinal synovial cysts of the lumbar spine: correlation of MR andsurgical findings. Neuroradiology. 2001;43(12):1070-5. doi: 10.1007/s002340100682.
17. Wilby MJ, Fraser RD, Vernon-Roberts B, Moore RJ. The prevalenceand pathogenesis of synovial cysts within the ligamentum flavum inpatients with lumbar spinal stenosis and radiculopathy. Spine (Phila Pa1976). 2009;34(23):2518-24. doi: 10.1097/BRS.0b013e3181b22bd0.
18. Yarde WL, Arnold PM, Kepes JJ, O’Boynick PL, Wilkinson SB,Batnitzky S. Synovial cysts of the lumbar spine: diagnosis, surgicalmanagement, and pathogenesis. Report of eight cases. Surg Neurol.1995;43(5):459-465. doi: 10.1016/0090-3019(95)80090-4.
19. Yurt A, Seçer M, Aydın M, Akçay E, Ertürk AR, Akkol İ, Yılmaz H,Palaz MN. Surgical management of Juxtafacet cysts in the lumbarspine. Int J Surg. 2016;29:9-11. doi: 10.1016/j.ijsu.2016.03.003.
Volume 1, Issue 1, 2023
Page : 1-6